Nutramedix, AMANTILLA - Relax / Sleep

ADHD

Razlog, R., Pellow, J., & White, S. J. (2012). A pilot study on the efficacy of Valeriana officinalis mother tincture and Valeriana officinalis 3X in the treatment of attention deficit hyperactivity disorder. Health SA Gesondheid (Online), 17(1), 1-7. Full Article

ANXIETY

Baek, J. H., Nierenberg, A. A., & Kinrys, G. (2014). Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. Australian & New Zealand Journal of Psychiatry, 48(8), 705-715. Full Article

CANCER

Hamaidia, M., Barez, P. Y., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., ... & Frederich, M. (2016). From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound. BASE.nano Full Article

COGNITIVE FUNCTION

Hassani, S., Alipour, A., Khezri, H. D., Firouzian, A., Zeydi, A. E., Baradari, A. G., ... & Zadeh, P. E. (2015). Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. Psychopharmacology, 232(5), 843-850. Full Article

DEPRESSION

Neamati, A., Chaman, F., Hosseini, M., & Boskabady, M. H. (2014). The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats. Journal of pharmacy & bioallied sciences, 6(2), 97. Full Article

Tang, J. Y., Zeng, Y. S., Chung, P., Wong, R., & Hagg, U. (2008). Effects of valeriana officinalis extract on rat depressive model. Journal of Chinese Clinical Medicine. Full Article

Salami, M. R., Safarnejad, A., & Hamidi, H. (2007). Effect of salinity stress on morphological characters of Cuminum cyminum and Valeriana officinalis. Pajouhesh and Sazandegi. Abstract

OROFACIAL DYSKINESIA

Fachinetto, R., Villarinho, J. G., Wagner, C., Pereira, R. P., Ávila, D. S., Burger, M. E., ... & Ferreira, J. (2007). Valeriana officinalis does not alter the orofacial dyskinesia induced by haloperidol in rats: role of dopamine transporter. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(7), 1478-1486. Full Article

OROFACIAL PAIN

Nowacki, L. C., Worfel, P. R., Martins, P. F. A., Santos, R. S. D., Stechman-Neto, J., & Souza, W. M. D. (2015). Analgesic effect of Hypericum perforatum, Valeriana officinalis and Piper methysticum for orofacial pain.Brazilian Journal of Oral Sciences, 14(1), 60-65. Full Article

PARKINSON DISEASE

de Oliveria, D. M., Barreto, G., De Andrade, D. V. G., Saraceno, E., Aon-Bertolino, L., Capani, F., ... & Giraldez, L. D. (2009). Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease. Neurochemical Research, 34(2), 215-220. Full Article

ANTI-INFLAMMATORY

Jacobo‐Herrera, N. J., Vartiainen, N., Bremner, P., Gibbons, S., Koistinaho, J., & Heinrich, M. (2006). F‐κB modulators from Valeriana officinalis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(10), 917-919. Full Article

ANTIOXIDANT

Кatsarova, М., Dimitrova, S., Lukanov, L., Sadakov, F., Denev, P., Plotnikov, E., ... & Kostadinova, I. (2017). Antioxidant activity and nontoxicity of extracts from Valeriana officinalis, Мelissa officinalis, Crataegus monogyna, Hypericum perforatum, Serratula coronatа and combinations Antistress 1 and Antistress 2. Full Article

Sudati, J. H., Vieira, F. A., Pavin, S. S., Dias, G. R. M., Seeger, R. L., Golombieski, R., ... & Barbosa, N. V. (2013). Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster. Neurotoxicology, 37, 118-126. Full Article

Sudati, J. H., Fachinetto, R., Pereira, R. P., Boligon, A. A., Athayde, M. L., Soares, F. A., ... & Rocha, J. B. T. (2009). In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. Neurochemical Research, 34(8), 1372. Full Article

ANXIOLYTIC

Murphy, K., Kubin, Z. J., Shepherd, J. N., & Ettinger, R. (2010). Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine, 17(8-9), 674-678. Full Article

Hattesohl, M., Feistel, B., Sievers, H., Lehnfeld, R., Hegger, M., & Winterhoff, H. (2008). Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties.Phytomedicine, 15(1-2), 2-15. Full Article

ANTICONVULSANT

Rezvani, M. E., Roohbakhsh, A., Allahtavakoli, M., & Shamsizadeh, A. (2010). Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. Journal of Ethnopharmacology, 127(2), 313-318. Full Article

Carrasco, M. C., Vallejo, J. R., Pardo‐de‐Santayana, M., Peral, D., Martín, M. Á., & Altimiras, J. (2009). Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam.Phytotherapy Research, 23(12), 1795-1796. Full Article

Hiller, K. O., & Zetler, G. (1996). Neuropharmacological studies on ethanol extracts of Valeriana officinalis L.: behavioural and anticonvulsant properties. Phytotherapy Research, 10(2), 145-151. Full Article

ANTIMICROBIAL

Letchamo, W., Ward, W., Heard, B., & Heard, D. (2004). Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. Journal of Agricultural and Food Chemistry, 52(12), 3915-3919. Abstract

GABA RECEPTOR MODULATOR

Ortiz, J. G., Nieves-Natal, J., & Chavez, P. (1999). Effects of Valeriana officinalis extracts on [3 H] flunitrazepam binding, synaptosomal [3 H] GABA uptake, and hippocampal [3 H] GABA release. Neurochemical research, 24(11), 1373-1378. Full Article

IMPROVED SLEEP QUALITY

Barton, D. L., Atherton, P. J., Bauer, B. A., Moore Jr, D. F., Mattar, B. I., LaVasseur, B. I., ... & Morgenthaler, T. I. (2011). The use of valeriana officinalis (valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study: NCCTG Trial, N01C5. The Journal of Supportive Oncology, 9(1), 24. Full Article

Murti, K., Kaushik, M., Sangwan, Y., & Kaushik, A. (2011). Pharmacological properties of Valeriana officinalis—a review. Pharmacologyonline, 3, 641-646. Full Article

Jacques Otobone, F., Colombo Martins, J. V., Trombelli, M. A., Andreatini, R., & Audi, E. A. (2005). Anxiolytic and sedative effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. in rats. Acta Scientiarum. Health Sciences, 27(2). Full Article

Fernández, S., Wasowski, C., Paladini, A. C., & Marder, M. (2004). Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacology Biochemistry and Behavior, 77(2), 399-404. Full Article

Leathwood, P. D., Chauffard, F., Heck, E., & Munoz-Box, R. (1982). Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacology Biochemistry and Behavior, 17(1), 65-71. Full Article

RELAXANT

Caudal, D., Guinobert, I., Lafoux, A., Bardot, V., Cotte, C., Ripoche, I., ... & Huchet, C. (2018). Skeletal muscle relaxant effect of a standardized extract of Valeriana officinalis L. after acute administration in mice. Journal of Traditional and Complementary Medicine, 8(2), 335-340. Full Article

Pilerood, S. A., & Prakash, J. (2013). Nutritional and medicinal properties of valerian (Valeriana officinalis) herb: A review. International Journal of Food, Nutrition and Dietetics, 1(1), 25. Full Article

Occhiuto, F., Pino, A., Palumbo, D. R., Samperi, S., De Pasquale, R., Sturlese, E., & Circosta, C. (2009). Relaxing effects of Valeriana officinalis extracts on isolated human non‐pregnant uterine muscle. Journal of Pharmacy and Pharmacology, 61(2), 251-256. Full Article

"This product is incredible.  I was very stressed out and within 10 minutes after taking just 10 drops, I felt no stress at all.  It works great for my kids too.  It's great to know that I can give them something natural and safe that can calm them down in a few minutes." -I.M.

“Amantilla works well. I use 15 drops in a little water just before going to sleep and it really makes a big difference.” – L.A

“I take 10 drops of this straight under my tongue before bed and start feeling calmer and ready for sleep immediately. It's also great to take before eating so the body can process food on a less-stressed stomach, but I don't always remember to take advantage of that... I'm planning to keep two bottles-- one by my bed and one in my purse to fix that problem!” – L.C

"I thought that I was sleeping well until I took Amantilla, but now I sleep great!  I took 30 drops at bedtime and I slept great.  I did not wake up once during the night and I woke up feeling very refreshed and didn't need coffee to get going.  Whenever I take it I can sleep about 2 hours less than I normally do."-T.I

Insomnia: take 30 drops in 4 oz. of water at bedtime.  

Severe Insomnia: take 30 drops every 30 minutes beginning 2 hours before bedtime for 5 nights.  

Mild Anxiety: take 10 drops 2-4 times per day.  

Moderate to Severe Anxiety, Panic Attacks: take 10-15 drops every 15 minutes in at least 2 oz. of water until symptoms are resolved. Can also put 2 droppers full (approximately 60 drops) in at least 480 ml (one pint) of water and sip over a 2-hour period, repeating until symptoms are resolved, then take 10 drops 2-4 times per day for maintenance.

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Amantilla did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article