Nutramedix, CHANCA PIEDRA - Stone Breaker

DENGUE VIRUS

Suresh, U., Murugan, K., Benelli, G., Nicoletti, M., Barnard, D. R., Panneerselvam, C., ... & Chandramohan, B. (2015). Tackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae). Parasitology Research, 114(4), 1551-1562. Full Article

DIABETES

Mediani, A., Abas, F., Maulidiani, M., Khatib, A., Tan, C. P., Ismail, I. S., ... & Lajis, N. H. (2016). Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract. Journal of Pharmaceutical and Biomedical Analysis, 128, 302-312. Full Article

Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., & Salawu, O. A. (2011). Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharmaceutical Biology, 49(3), 248-255. Full Article

Okoli, C. O., Ibiam, A. F., Ezike, A. C., Akah, P. A., & Okoye, T. C. (2010). Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats. African Journal of Biotechnology, 9(2). Full Article

Bavarva, J. H., & Narasimhacharya, A. V. R. L. (2007). Comparative Antidiabetic, Hypolipidemic, and Antioxidant Properties of Phyllanthus niruri. in Normal and Diabetic Rats. Pharmaceutical Biology, 45(7), 569-574. Full Article

HEPATITIS B

Liu, S., Wei, W., Li, Y., Lin, X., Shi, K., Cao, X., & Zhou, M. (2014). In vitro and in vivo anti-hepatitis B virus activities of the lignan nirtetralin B isolated from Phyllanthus niruri L. Journal of Ethnopharmacology, 157, 62-68. Full Article

Wei, W., Li, X., Wang, K., Zheng, Z., & Zhou, M. (2012). Lignans with Anti‐Hepatitis B Virus Activities from Phyllanthus niruri L. Phytotherapy Research, 26(7), 964-968. Full Article

HIV

Naik, A. D., & Juvekar, A. R. (2003). Effects of alkaloidal extract of Phyllanthus niruri on HIV replication. Indian Journal of Medical Sciences, 57(9), 387-393. Full Article

LIVER CIRRHOSIS

Amin, Z. A., Bilgen, M., Alshawsh, M. A., Ali, H. M., Hadi, A. H. A., & Abdulla, M. A. (2012). Protective role of Phyllanthus niruri extract against thioacetamide-induced liver cirrhosis in rat model. Evidence-Based Complementary and Alternative Medicine, 2012. Full Article

UROLITHIASIS (KIDNEY STONES)

Boim, M. A., Heilberg, I. P., & Schor, N. (2010). Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. International Braz J Urol, 36(6), 657-664. Full Article

MALARIA

Tona, L., Mesia, K., Ngimbi, N. P., Chrimwami, B., Okond'Ahoka, Cimanga, K., ... & Pieters, L. (2001). In-vivo antimalarial activity of Cassia occidentalism Morinda morindoides and Phyllanthus niruri. Annals of Tropical Medicine & Parasitology, 95(1), 47-57. Full Article

TUMORS

Sharma, P., Parmar, J., Verma, P., Sharma, P., & Goyal, P. K. (2009). Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac J Cancer Prev, 10(6), 1089-1094. Full Article

ANTIBACTERIAL

Ekwenye, U. N., & Njoku, N. U. (2006). Antibacterial effect of Phyllanthus niruri (Chanca Piedra) on three enteropathogens in Man. International Journal of Molecular Medicine and Advance Sciences, 2(2), 184-189. Full Article

ANTIHYPERURICEMIC

Murugaiyah, V., & Chan, K. L. (2009). Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. Journal of Ethnopharmacology, 124(2), 233-239. Full Article

ANTIOXIDANT

Navarro, M., Moreira, I., Arnaez, E., Quesada, S., Azofeifa, G., Alvarado, D., & Monagas, M. J. (2017). Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd. Plants, 6(4), 50. Full Article

Sabir, S. M., & Rocha, J. B. T. (2008). Water-extractable phytochemicals from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice. Food Chemistry, 111(4), 845-851. Full Article

Bhattacharjee, R., & Sil, P. C. (2007). Protein isolate from the herb, Phyllanthus niruri L.(Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food and Chemical Toxicology, 45(5), 817-826. Full Article

Chatterjee, M., Sarkar, K., & Sil, P. C. (2006). Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress.Pathophysiology, 13(2), 95-102. Full Article

Chatterjee, M., & Sil, P. C. (2006). Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian Journal of Biochemistry & Biophysics, 43, 299-305. Full Article

Bhattacharjee, R., & Sil, P. C. (2006). The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(7), 595-601. Full Article

Harish, R., & Shivanandappa, T. (2006). Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chemistry, 95(2), 180-185. Full Article

ANTIMICROBIAL

Ranilla, L. G., Apostolidis, E., & Shetty, K. (2012). Antimicrobial activity of an Amazon medicinal plant (Chancapiedra)(Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria.Phytotherapy Research, 26(6), 791-799. Full Article

ANTI-INFLAMMATORY

Mostofa, R., Ahmed, S., Begum, M. M., Rahman, M. S., Begum, T., Ahmed, S. U., ... & Begum, R. (2017). Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L.(Euphorbiaceae) leaves in experimental rats. BMC complementary and alternative medicine, 17(1), 267. Full Article

ANTIPLASMODIAL

Ifeoma, O., Samuel, O., Itohan, A. M., & Adeola, S. O. (2013). Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pacific Journal of Tropical Medicine, 6(3), 169-175. Full Article

Soh, P. N., Banzouzi, J. T., Mangombo, H., Lusakibanza, M., Bulubulu, F. O., Tona, L., ... & Luyindula, S. N. (2009). Antiplasmodial activity of various parts of Phyllanthus niruri according to its geographical distribution. African journal of Pharmacy and Pharmacology, 3(12), 598-601. Full Article

Mustofa, S. E., & Wahyuono, S. (2007). In vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of Phyllanthus niruri L. herbs traditionally used to treat malaria in Indonesia. Southeast Asian J Trop Med Public Health, 38(4), 609-615. Full Article

Cimanga, R. K., Tona, L., Luyindula, N., Mesia, K., Lusakibanza, M., Musuamba, C. T., ... & Totté, J. (2004). In vitro antiplasmodial activity of callus culture extracts and fractions from fresh apical stems of Phyllanthus niruri L.(Euphorbiaceae): part 2.Journal of Ethnopharmacology, 95(2-3), 399-404. Full Article

HEPATOPROTECTIVE

Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236-243. Full Article

IBS

Giribabu, N., Rao, P. V., Kumar, K. P., Muniandy, S., Swapna Rekha, S., & Salleh, N. (2014). Aqueous extract of Phyllanthus niruri leaves displays in vitro antioxidant activity and prevents the elevation of oxidative stress in the kidney of streptozotocin-induced diabetic male rats. Evidence-Based Complementary and Alternative Medicine, 2014. Full Article

IMMUNOMODULATING

Nworu, C. S., Akah, P. A., Okoye, F. B. C., Proksch, P., & Esimone, C. O. (2010). The effects of Phyllanthus niruri aqueous extract on the activation of murine lymphocytes and bone marrow-derived macrophages. Immunological investigations, 39(3), 245-267. Full Article

VARIOUS PROPERTIES

Amin, Z. A., Abdulla, M. A., Ali, H. M., Alshawsh, M. A., & Qadir, S. W. (2012). Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri. Journal of the Science of Food and Agriculture, 92(9), 1874-1877. Full Article

Bagalkotkar, G., Sagineedu, S. R., Saad, M. S., & Stanslas, J. (2006). Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. Journal of Pharmacy and Pharmacology, 58(12), 1559-1570. Full Article

"My daughter was turning 37 and wound up in the hospital on her birthday with a kidney stone.  The ER doctor told her that it was small so she'd have to pass it.  She was in so much pain.  She was so upset that she went home and started researching passing stones on the internet.  Chanca Piedra had just been released on the NutraMedix website so she placed her order and it arrived the next day.  She started feeling better IMMEDIATELY and was totally out of pain within 3 hours."-T.M.

30 drops twice daily at least 30 minutes before meals (start with 2-4 drops in 4 oz. of water adding 2-4 drops with each dose as tolerated, taking remedies for Herxheimer reactions if needed).