ALZHEIMER’S DISEASE
Researchers Report That a Natural Plant Derivative From the Amazon Rain Forest in a Rodent Model Inhibits the Deposition of Beta-amyloid Deposits Associated With Alzheimer's Disease Plaques.. (n.d.) >The Free Library. (2014). Retrieved Jun 20 2018 from Full Article
BLADDER CANCER
Dietrich, F., Kaiser, S., Rockenbach, L., Figueiró, F., Bergamin, L. S., da Cunha, F. M., ... & Battastini, A. M. O. (2014). Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line. Food and chemical toxicology, 67, 222-229. Full Article
BRAIN CANCER
Prado, E. G., Gimenez, M. G., De la Puerta Vázquez, R., Sánchez, J. E., & Rodriguez, M. S. (2007). Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine, 14(4), 280-284. Full Article
BREAST CANCER
Baraya, Y. U. S. A. B., Wong, K. K., & Yaacob, N. S. (2017). The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: a review. Anti-Cancer Agents in Medicinal Chemistry(Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 17(6), 770-783. Full Article
García Giménez, M. D., García Prado, E., Sáenz Rodríguez, M. T., Fernández Arche, M. D. L. Á., & Puerta Vázquez-Zafra, R. D. L. (2010). Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines. Planta Medica, 76, 133-136. Full Article
Riva, L., Coradini, D., Di, G. F., De, V. F., De, N. T., De, F. S., & Pizza, C. (2001). The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Research, 21(4A), 2457-2461. Full Article
CYSTITIS
Dietrich, F., Martins, J. P., Kaiser, S., Silva, R. B. M., Rockenbach, L., Edelweiss, M. I. A., ... & Battastini, A. M. O. (2015). The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice. PloS one, 10(7), e0131882. Full Article
DENGUE FEVER
Reis, S. R. I., Valente, L. M., Sampaio, A. L., Siani, A. C., Gandini, M., Azeredo, E. L., ... & Kubelka, C. F. (2008). Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2. International Immunopharmacology, 8(3), 468-476. Full Article
DENTURE STOMATITIS
Tay, L. Y., Dos Santos, F. A., & Jorge, J. H. (2015). Uncaria tomentosa gel against denture stomatitis: clinical report. Journal of Prosthodontics, 24(7), 594-597. Full Article
ENDOMETRIOSIS
Neto, J. N., Coelho, T. M., Aguiar, G. C., Carvalho, L. R., de Araújo, A. G. P., Girão, M. J. B., & Schor, E. (2011). Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract. European Journal of Obstetrics and Gynecology and Reproductive Biology, 154(2), 205-208. Full Article
HERPES
Caon, T., Kaiser, S., Feltrin, C., de Carvalho, A., Sincero, T. C. M., Ortega, G. G., & Simões, C. M. O. (2014). Antimutagenic and antiherpetic activities of different preparations from Uncaria tomentosa (cat’s claw). Food and Chemical Toxicology, 66, 30-35. Full Article
IMMUNE-MEDIATED DISEASES (DIABETES)
Domingues, A., Sartori, A., Golim, M. A., Valente, L. M. M., da Rosa, L. C., Ishikawa, L. L. W., ... & Viero, R. M. (2011). Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?. Journal of Ethnopharmacology, 137(1), 635-642. Full Article
Yessoufou, A., Gbenou, J., Grissa, O., Hichami, A., Simonin, A. M., Tabka, Z., ... & Khan, N. A. (2013). Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferation. BMC complementary and alternative medicine, 13(1), 77. Full Article
Araujo, L. C., Feitosa, K. B., Murata, G. M., Furigo, I. C., Teixeira, S. A., Lucena, C. F., ... & Bordin, S. (2018). Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD.Scientific reports, 8(1), 11013. Full Article
Domingues, A., Sartori, A., Golim, M. A., Valente, L. M. M., da Rosa, L. C., Ishikawa, L. L. W., ... & Viero, R. M. (2011). Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?. Journal of ethnopharmacology, 137(1), 635-642. Full Article
Mahmoudian-Sani, M., Luther, T., Asadi-Samani, M., Saeedi-Boroujeni, A., & Gholamian, N. (2017). A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells. J Renal Inj Prev, 6(3), 158-63. Full Article
Pane, Y. S., Ganie, R. A., Lindarto, D., & Lelo, A. (2018). The Effect of Gambier Extract on the Levels of Malondialdehyde, Superoxide Dismutase, and Blood Glucose in Type 2 Diabetes Mellitus Patients. Asian J Pharm Clin Res, 11(10), 121-124. Full Article
LEUKEMIA
Pilarski, R., Poczekaj-Kostrzewska, M., Ciesiolka, D., Szyfter, K., & Gulewicz, K. (2007). Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells.Pharmacological reports, 59(5), 565. Full Article
LISTERIA
Eberlin, S., dos Santos, L. M., & Queiroz, M. L. (2005). Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes. International Immunopharmacology, 5(7-8), 1235-1246. Full Article
OSTEOARTHRITIS
Piscoya, J., Rodriguez, Z., Bustamante, S. A., Okuhama, N. N., Miller, M. J. S., & Sandoval, M. (2001). Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflammation Research, 50(9), 442-448. Full Article
RHEUMATOID ARTHRITIS
Mur, E., Hartig, F., Eibl, G., & Schirmer, M. (2002). Randomized double-blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis.The Journal of Rheumatology, 29(4), 678-681. Full Article
SKIN CANCER
Ciani, F., Tafuri, S., Troiano, A., Cimmino, A., Fioretto, B. S., Guarino, A. M., ... & Calabrò, V. (2018). Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cells. Journal of Ethnopharmacology, 211, 285-294. Full Article
THYROID CANCER
Rinner, B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R. (2009). Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells. Anticancer Research, 29(11), 4519-4528. Full Article
TUMORS
Santos, K. F., Gutierres, J. M., Pillat, M. M., Rissi, V. B., dos Santos Araújo, M. D. C., Bertol, G., ... & Morsch, V. M. (2016). Uncaria tomentosa extract alters the catabolism of adenine nucleotides and expression of ecto-5′-nucleotidase/CD73 and P2X7 and A1 receptors in the MDA-MB-231 cell line. Journal of Ethnopharmacology, 194, 108-116. Full Article
de Paula, L. C. L., Fonseca, F., Perazzo, F., Cruz, F. M., Cubero, D., Trufelli, D. C., ... & del Giglio, A. (2015). Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. The Journal of Alternative and Complementary Medicine, 21(1), 22-30. Full Article
Dreifuss, A. A., Bastos-Pereira, A. L., Ávila, T. V., da Silva Soley, B., Rivero, A. J., Aguilar, J. L., & Acco, A. (2010). Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa)(Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model. Journal of Ethnopharmacology,130(1), 127-133. Full Article