FOR:

VIRAL INFECTIONS
INFLAMMATION
IMMUNE SYSTEM MODULATION

General Description

Noni is a tropical fruit that is grown in the Pacific Islands. It has been successfully used for over 2000 years in Polynesia to treat a variety of illnesses. The most beneficial Noni is grown organically in pollution free volcanic soil. James Howenstine, MD, and other medical doctors report that the Nutramedix Noni extract can eliminate the symptoms associated with colds and flu within 3 to 4 hours. Physicians report that 30 ml (one ounce) of Nutramedix Noni extract is as effective as up to 8 liters or 8 quarts of Noni juice from other companies.

Some Reported Medicinal Properties

ADAPTOGEN

ANALGESIC

ANTICANCEROUS

ANTI-INFLAMMATORY

ANTIMICROBIAL

ANTIMUTAGENIC

ANTI-ULCEROUS

IMMUNOMODULATOR

SEDATIVE

Research On NutraMedix Product

IN VIVO – ANTI-INFLAMMATORY EFFECT

Establishment of the Potential Anti-inflammatory Effect of the product known as Noni. The study demonstrated that Noni had a marked anti-inflammatory effect and was 99% as effective as Feldene, a non-steroidal anti-inflammatory drug also known as PIROXICAM. University of Guayaquil, Department of Chemical Sciences, Guayaquil, Ecuador (2005) Full Article

Establishment of the Potential Anti-inflammatory Effect of the product known as Noni. The study demonstrated that Noni had a marked anti-inflammatory effect and was 112% as effective as Celebrex, a non-steroidal anti-inflammatory drug also known as PIROXICAM. University of Guayaquil, Department of Chemical Sciences, Guayaquil, Ecuador (2005) Full Article

IN VIVO – ACUTE ORAL TOXICITY TESTS

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Noni did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

Medical Conditions [peer-reviewed journals]

CANCER

Brown, A. C. (2012). Anticancer activity of Morinda citrifolia (Noni) fruit: a review. Phytotherapy Research, 26(10), 1427-1440. Full Article

Lv, L., Chen, H., Ho, C. T., & Sang, S. (2011). Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects. Fitoterapia, 82(4), 704-708. Full Article

Thani, W., Vallisuta, O., Siripong, P., & Ruangwises, N. (2010). Anti-proliferative and antioxidative activities of Thai noni/Yor (Morinda citrifolia Linn.) leaf extract. Southeast Asian J trop med public health, 41(2), 482-.489. Full Article

Wang, M. Y., Peng, L., Lutfiyya, M. N., Henley, E., Weidenbacher-Hoper, V., & Anderson, G. (2009). Morinda citrifolia (noni) reduces cancer risk in current smokers by decreasing aromatic DNA adducts. Nutrition and cancer, 61(5), 634-639. Full Article

Chan-Blanco, Y., Vaillant, F., Perez, A. M., Reynes, M., Brillouet, J. M., & Brat, P. (2006). The noni fruit (Morinda citrifolia L.): A review of agricultural research, nutritional and therapeutic properties. Journal of Food Composition and Analysis, 19(6-7), 645-654. Full Article

Wang, M. Y., & Su, C. (2001). Cancer preventive effect of Morinda citrifolia (Noni). Annals of the New York Academy of Sciences, 952(1), 161-168. Full Article

Anekpankul, T., Goto, M., Sasaki, M., Pavasant, P., & Shotipruk, A. (2007). Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water. Separation and Purification Technology, 55(3), 343-349. Full Article

DIABETES

Lee, S. Y., Park, S. L., Hwang, J. T., Yi, S. H., Nam, Y. D., & Lim, S. I. (2012). Antidiabetic effect of Morinda citrifolia (Noni) fermented by Cheonggukjang in KK-Ay diabetic mice. Evidence-Based Complementary and Alternative Medicine, 2012. Full Article

Medicinal Properties [peer-reviewed journals]

ANTIOXIDANT

Pavithra, S., & Banu, N. (2017). Free Radical Scavenging Activity and Total Antioxidant Capacity of Tin Chlorophyllin from Morinda citrifolia L. Research Journal of Pharmacy and Technology, 10(2), 453-455. Full Article

Krishnaiah, D., Bono, A., Sarbatly, R., & Anisuzzaman, S. M. (2015). Antioxidant activity and total phenolic content of an isolated Morinda citrifolia L. methanolic extract from Poly-ethersulphone (PES) membrane separator. Journal of King Saud University-Engineering Sciences, 27(1), 63-67. Full Article

de Almeida Brito, F., de Oliveira Barreto, E., Serafini, M. R., dos Santos, J. P. A., dos Santos Lima, B., Walker, C. I. B., ... & de Souza Araujo, A. A. (2015). Anti-inflammatory property and redox profile of the leaves extract from Morinda citrifolia L. Journal of Medicinal Plants Research, 9(24), 693-701. Full Article

Piaru, S. P., Mahmud, R., Abdul Majid, A. M., & Mahmoud Nassar, Z. D. (2012). Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Asian Pac J Trop Med, 5(4), 294-298. Full Article

Serafini, M. R., Santos, R. C., Guimaraes, A. G., dos Santos, J. P. A., da Conceicao Santos, A. D., Alves, I. A., ... & de Souza Araújo, A. A. (2011). Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration. Journal of Medicinal Food, 14(10), 1159-1166. Full Article

Masuda, M., Murata, K., Fukuhama, A., Naruto, S., Fujita, T., Uwaya, A., ... & Matsuda, H. (2009). Inhibitory effects of constituents of Morinda citrifolia seeds on elastase and tyrosinase. Journal of Natural Medicines, 63(3), 267-273. Full Article

Liu, C. H., Xue, Y. R., Ye, Y. H., Yuan, F. F., Liu, J. Y., & Shuang, J. L. (2007). Extraction and characterization of antioxidant compositions from fermented fruit juice of Morinda citrifolia (Noni). Agricultural Sciences in China, 6(12), 1494-1501. Full Article

Ramamoorthy, P. K., & Bono, A. (2007). Antioxidant activity, total phenolic and flavonoid content of Morinda citrifolia fruit extracts from various extraction processes. Journal of Engineering Science and Technology, 2(1), 70-80. Full Article

Yang, J. I. A. N., Gadi, R. A. M. A., & Thomson, T. A. L. E. N. E. (2011). Antioxidant capacity, total phenols, and ascorbic acid content of noni (Morinda citrifolia) fruits and leaves at various stages of maturity. Micronesica, 41(2), 167-176. Full Article

Yang, J., Paulino, R., Janke-Stedronsky, S., & Abawi, F. (2007). Free-radical-scavenging activity and total phenols of noni (Morinda citrifolia L.) juice and powder in processing and storage. Food Chemistry, 102(1), 302-308. Full Article

Zin, Z. M., Abdul-Hamid, A., & Osman, A. (2002). Antioxidative activities of chromatographic fractions obtained from root, fruit and leaf of Mengkudu (Morinda citrifolia L.) Food Chemistry, 78(2), 227-231. Full Article

ANTIDEPRESSENT

Deng, S., & West, B. J. (2011). Antidepressant effects of noni fruit and its active principals. Asian J Med Sci, 3(2), 79-83. Full Article

ANTIFUNGAL

Jainkittivong, A., Butsarakamruha, T., & Langlais, R. P. (2009). Antifungal activity of Morinda citrifolia fruit extract against Candida albicans. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 108(3), 394-398. Full Article

ANTIBACTERIAL

Silva, A. R. N., Ranaweera, C. B., Karunathilaka, R. N., Pathirana, R., & Ratnasooriya, W. D. (2016). Antibacterial activity of water extracts of different parts of Morinda citrifolia grown in Sri Lanka. Int J Sci Res Publ, 6, 124-7. Full Article

Schäfer, M., Sharp, P., Brooks, V. J., Xu, J., Cai, J., Keuler, N. S., ... & Darien, B. J. (2008). Enhanced bactericidal activity against Escherichia coli in calves fed Morinda citrifolia (Noni) puree. Journal of veterinary internal medicine, 22(2), 499-502. Full Article

Jayaraman, S. K., Manoharan, M. S., & Illanchezian, S. (2008). Antibacterial, antifungal and tumor cell suppression potential of Morinda citrifolia fruit extracts. International Journal of Integrative Biology, 3(1), 44-49. Full Article

De La Cruz-Sánchez, N. G., Gómez-Rivera, A., Alvarez-Fitz, P.,Ventura-Zapata, E., Pérez-García, M. D., Avilés-Flores, M., ... &González-Cortazar, M. (2019). Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-Resistant Staphylococcus spp. Microbial pathogenesis, 128,347-353. Full Article

ANTI-TUMOR

Furusawa, E., Hirazumi, A., Story, S., & Jensen, J. (2003). Antitumour potential of a polysaccharide‐rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 17(10), 1158-1164. Full Article

ANTIULCER

Muralidharan, P., & Srikanth, J. (2009). Antiulcer activity of Morinda citrifolia Linn fruit extract. J Sci Res, 1(2), 345-352. Full Article

ANTIMICROBIAL

Usha, R., Sashidharan, S., & Palaniswamy, M. (2010). Antimicrobial Activity of a Rarely Known Species, Morinda citrifolia L. Ethnobotanical Leaflets, 2010(3), 7. Full Article

ANTI-INFLAMMATORY

Sousa, S. G., Oliveira, L. A., de Aguiar Magalhães, D., de Brito, T. V., Batista, J. A., Pereira, C. M. C., ... & da Silva, D. A. (2018). Chemical structure and anti-inflammatory effect of Polysaccharide extracted from Morinda citrifolia Linn (Noni). Carbohydrate Polymers. Full Article

Dussossoy, E., Bichon, F., Bony, E., Portet, K., Brat, P., Vaillant, F., ... & Poucheret, P. (2016). Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice (Morinda citrifolia L.). Journal of Ethnopharmacology, 192, 264-272. Full Article

Huang, H. L., Liu, C. T., Chou, M. C., Ko, C. H., & Wang, C. K. (2015). Noni (Morinda citrifolia L.) fruit extracts improve colon microflora and exert anti-inflammatory activities in Caco-2 cells. Journal of medicinal food, 18(6), 663-676. Full Article

Nitteranon, V., Zhang, G., Darien, B. J., & Parkin, K. (2011). Isolation and synergism of in vitro anti-inflammatory and quinone reductase (QR) inducing agents from the fruits of Morinda citrifolia (noni). Food research international, 44(7), 2271-2277. Full Article

Dussossoy, E., Brat, P., Bony, E., Boudard, F., Poucheret, P., Mertz, C., ... & Michel, A. (2011). Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.). Journal of ethnopharmacology, 133(1), 108-115. Full Article

Basar, S., Uhlenhut, K., Högger, P., Schöne, F., & Westendorf, J. (2010). Analgesic and antiinflammatory activity of Morinda citrifolia L.(Noni) fruit. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 24(1), 38-42. Full Article

Akihisa, T., Matsumoto, K., Tokuda, H., Yasukawa, K., Seino, K. I., Nakamoto, K., ... & Kimura, Y. (2007). Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni). Journal of Natural Products, 70(5), 754-757. Full Article

Mckoy, M. G., Thomas, E. A., & Simon, O. R. (2002). Preliminary investigation of the anti-inflammatory properties of an aqueous extract from Morinda citrifolia (Noni). In Proceedings of the Western Pharmacology Society (Vol. 45, pp. 76-78). Seattle, Wash.: The Society. Full Article

ATHLETIC ENDURANCE

Anekpankul, T., Goto, M., Sasaki, M., Pavasant, P., & Shotipruk, A. (2007). Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water. Separation and Purification Technology, 55(3), 343-349. Full Article

HEPATOTOXICITY

Wang, M. Y., Anderson, G., Nowicki, D., & Jensen, J. (2008). Hepatic protection by noni fruit juice against CCl 4-induced chronic liver damage in female SD rats. Plant foods for human nutrition, 63(3), 141-145. Full Article

Stadlbauer, V., Fickert, P., Lackner, C., Schmerlaib, J., Krisper, P., Trauner, M., & Stauber, R. E. (2005). Hepatotoxicity of NONI juice: report of two cases. World journal of gastroenterology: WJG, 11(30), 4758. Full Article

IMMUNOMODULATING

Palu, A. K., Kim, A. H., West, B. J., Deng, S., Jensen, J., & White, L. (2008). The effects of Morinda citrifolia L.(noni) on the immune system: its molecular mechanisms of action. Journal of Ethnopharmacology, 115(3), 502-506. Full Article

Nayak, S., & Mengi, S. (2010). Immunostimulant activity of noni (Morinda citrifolia) on T and B lymphocytes. Pharmaceutical biology, 48(7), 724-731. Full Article

MEMORY IMPROVEMENT

Pachauri, S. D., Tota, S., Khandelwal, K., Verma, P. R. P., Nath, C., Hanif, K., ... & Dwivedi, A. K. (2012). Protective effect of fruits of Morinda citrifolia L. on scopolamine induced memory impairment in mice: a behavioral, biochemical and cerebral blood flow study. Journal of ethnopharmacology, 139(1), 34-41. Full Article

NEURON PROTECTION

Harada, S., Hamabe, W., Kamiya, K., Satake, T., Yamamoto, J., & Tokuyama, S. (2009). Preventive effect of Morinda citrifolia fruit juice on neuronal damage induced by focal ischemia. Biological and Pharmaceutical Bulletin, 32(3), 405-409. Full Article

WOUND HEALING

Nayak, B. S., Sandiford, S., & Maxwell, A. (2009). Evaluation of the wound-healing activity of ethanolic extract of Morinda citrifolia L. leaf. Evidence-Based Complementary and Alternative Medicine, 6(3), 351-356. Full Article

VARIOUS PROPERTIES

Assi, R. A., Darwis, Y., Abdulbaqi, I. M., Vuanghao, L., & Laghari, M. H. (2017). Morinda citrifolia (Noni): A comprehensive review on its industrial uses, pharmacological activities, and clinical trials. Arabian Journal of Chemistry, 10(5), 691-707. Full Article

Singh, D. R. (2012). Morinda citrifolia L.(Noni): A review of the scientific validation for its nutritional and therapeutic properties. Journal of Diabetes and Endocrinology, 3(6), 77-91. Full Article

Patient Reports

“Noni is a very good supplement and helps with immune system.” – M.Z

"I bought this after reading an article about how it can knock out colds and flu within hours. I used it several times when I felt like I was fighting a cold and never got the cold. However, the real test came a few days ago when I was traveling with my 14 and 17-year-old. They both started complaining of bad sore throats and felt like they were getting sick. I pulled out the Noni, (I always know when my kids are actually sick because it is the only time they're willing to take supplements.) Ever skeptical about anything mom gives them, they nonetheless took it and were both amazed when they actually felt better within hours. Great stuff!!" -R.P.

“Really knocks a cold out of your system fast.” – L.A.

“This noni worked Really well preventing me from having gout attacks!” – D.D

"NutraMedix Noni is the best Noni I've ever used. NutraMedix is a small bottle but it actually is a better buy because you don't have to drink it like a shot of liquor like you do with most Noni juices."-A.J.

Dosage Information

15 to 30 drops twice daily (start with 15 drops adding two drops with each dose until you reach 30). May be taken hourly for acute health challenges.

Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Noni did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

Nutramedix, NONI -MICROBIAL DEFENSE Nutramedix, NONI -MICROBIAL DEFENSE