Nutramedix, PINELLA- BRAIN-NERVE CLEANSE Nutramedix, PINELLA- BRAIN-NERVE CLEANSE

Pinella – Brain & Nerve Cleanse is an herbal extract made from Pimpinella anisum. It has been used by indigenous groups for hundreds of years. Pinella is an integral component of a Lyme disease protocol developed by William Lee Cowden, MD.  Dr. Cowden and other health care professionals report that it is very effective in eliminating both man-made toxins and biotoxins from the brain, the spinal cord and peripheral nerves. Both patients and health care professionals also report that many times there is a significant reduction in brain fog, even after only one dose.

ANALGESIC

ANODYNE

ANTI-BACTERIAL

ANTI-CONVULSANT

ANTI-FUNGAL

ANTI-MICROBIAL

ANTIOXIDANT

ANTIVIRAL

APHRODISIAC

AROMATIC

CARMINATIVE

DIAPHORIC

DISINFECTANT

DIURETIC

DYSMENORRHEA

GALACTAGOGUE

HYPOGLYCEMIC

HYPOLIPIDEMIC

MENOPAUSAL HOT FLASHES

MUSCLE RELAXANT

NERVINE

STIMULANT

SUDORIFIC

FATTY LIVER DISEASE

Asadollahpoor, A., Abdollahi, M., & Rahimi, R. (2017). Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 22. Article

CANCER

AlSalhi, M. S., Devanesan, S., Alfuraydi, A. A., Vishnubalaji, R., Munusamy, M. A., Murugan, K., ... & Benelli, G. (2016). Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells. International Journal of Nanomedicine, 11, 4439. Full Article

Fitsiou, E., Mitropoulou, G., Spyridopoulou, K., Tiptiri-Kourpeti, A., Vamvakias, M., Bardouki, H., ... & Pappa, A. (2016). Phytochemical Profile and evaluation of the biological activities of essential oils derived from the Greek aromatic plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita. Molecules, 21(8), 1069. Full Article

Kadan, S., Rayan, M., & Rayan, A. (2013). Anticancer activity of anise (Pimpinella anisum L.) seed extract. The Open Nutraceuticals Journal, 6(1). Full Article

DEPRESSION

Shahamat, Z., Abbasi-Maleki, S., & Motamed, S. M. (2016). Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice. Avicenna journal of phytomedicine, 6(3), 322. Full Article

DIABETES

Shobha, R. I., Rajeshwari, C. U., & Andallu, B. (2013). Anti-peroxidative and anti-diabetic activities of aniseeds (Pimpinella anisum L.) and identification of bioactive compounds. American Journal of Phytomedicine and Clinical Therapeutics, 1(5), 516-527. Full Article

ANTIBACTERIAL

Foroughi, A., Pournaghi, P., Tahvilian, R., Zangeneh, M. M., Zangeneh, A., & Moradi, R. (2016). Assessment of chemical composition and antibacterial effects of Anethole-rich hydroalcoholic extract of Pimpinella anisum. International Journal of Pharmaceutical and Clinical Research, 8(11), 1459-1463. Full Article

Al Maofari, A., El Hajjaji, S., Debbab, A., Zaydoun, S., Ouaki, B., Charof, R., ... & Mosaddak, M. (2013). Chemical composition and antibacterial properties of essential oils of Pimpinella Anisum L. growing in Morocco and Yemen. Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry, 14(1), 11. Full Article

Al-Bayati, F. A. (2008). Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts. Journal of Ethnopharmacology, 116(3), 403-406. Full Article

Akhtar, A., Deshmukh, A. A., Bhonsle, A. V., Kshirsagar, P. M., & Kolekar, M. A. (2008). In vitro antibacterial activity of Pimpinella anisum fruit extracts against some pathogenic bacteria. Veterinary World, 1(9), 272-274. Full Article

ANTIOXIDANT

Rebey, I. B., Wannes, W. A., Kaab, S. B., Bourgou, S., Tounsi, M. S., Ksouri, R., & Fauconnier, M. L. (2019). Bioactive compounds and antioxidant activity of Pimpinella anisum L. accessions at different ripening stages. Scientia Horticulturae, 246, 453-461. Full Article

Tavallali, V., Rahmati, S., & Bahmanzadegan, A. (2017). Antioxidant activity, polyphenolic contents and essential oil composition of Pimpinella anisum L. as affected by zinc fertilizer. Journal of the Science of Food and Agriculture, 97(14), 4883-4889. Full Article

Jamshidzadeh, A., Heidari, R., Razmjou, M., Karimi, F., Moein, M. R., Farshad, O., ... & Shayesteh, M. R. H. (2015). An in vivo and in vitro investigation on hepatoprotective effects of Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity. Iranian Journal of Basic Medical Sciences, 18(2), 205. Full Article

Singh, G., Kapoor, I. P. S., Singh, P., de Heluani, C. S., & Catalan, C. A. N. (2008). Chemical composition and antioxidant potential of essential oil and oleoresins from anise seeds (Pimpinella anisum L.). International Journal of Essential Oil Therapeutics, 2(3), 122-130. Full Article

Gülçın, İ., Oktay, M., Kıreçcı, E., & Küfrevıoǧlu, Ö. İ. (2003). Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chemistry, 83(3), 371-382. Full Article

ANTICONVULSANT

Karimzadeh, F., Hosseini, M., Mangeng, D., Alavi, H., Hassanzadeh, G. R., Bayat, M., ... & Gorji, A. (2012). Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. BMC Complementary and Alternative Medicine, 12(1), 76. Full Article

Pourgholami, M. H., Majzoob, S., Javadi, M., Kamalinejad, M., Fanaee, G. H. R., & Sayyah, M. (1999). The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. Journal of Ethnopharmacology, 66(2), 211-215. Full Article

‍ANTIFUNGAL

El-Said, A. H. M., & Goder, E. (2014). Antifungal activities of Cuminum cyminum and Pimpinella anisum essential oils. Int. J. Curr. Microbiol. App. Sci, 3(3), 937-944. Full Article

Yazdani, D., Rezazadeh, S. H., Amin, G. H., Abidin, Z., Shahnazi, S., & Jamalifar, H. (2009). Antifungal activity of dried extracts of anise (Pimpinella anisum L.) and star anise (Illicium verum Hook. f.) against dermatophyte and saprophyte fungi. Journal of Medicinal Plants, 1(29), 24-29. Full Article

Sharifi, R., Kiani, H., Farzaneh, M., & Ahmadzadeh, M. (2008). Chemical composition of essential oils of Iranian Pimpinella anisum L. and Foeniculum vulgare miller and their antifungal activity against post harvest pathogens. Journal of Essential Oil Bearing Plants, 11(5), 514-522. Full Article

Kosalec, I., Pepeljnjak, S., & Kuštrak, D. (2005). Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharmaceutica, 55(4), 377-385. Full Article

Shukla, H. S., & Tripathi, S. G. (1987). Antifungal substance in the essential oil of anise (Pimpinella anisum L.). Agricultural and Biological Chemistry, 51(7), 1991-1993. Full Article

Alrasheid, A. A., Abdallah, B. S., & Ali, A. O. (2018). In Vitro Antimicrobial Activity and GC-MS Analysis of Seed Extracts from Pimpinella anisum L. Journal of Drug Design and Medicinal Chemistry, 4(2), 16-21. Full Article

ANTIMICROBIAL

Mohamed, H. S. A. A., Abdelgadir, W. S., & Almagboul, A. Z. (2015). In vitro antimicrobial activity of Anise seed (Pimpinella anisum L.). International Journal of Advanced Research, 3(1), 359-367. Full Article

Mohammed, M. J. (2009). Isolation and identification of Anethole from Pimpinella anisum L. fruit oil. Anantimicrobial study. J Pharma Res 2009; 915, 919. Full Article

Gende, L. B., Maggi, M. D., Fritz, R., Eguaras, M. J., Bailac, P. N., & Ponzi, M. I. (2009). Antimicrobial activity of Pimpinella anisum and Foeniculum vulgare essential oils against Paenibacillus larvae. Journal of Essential Oil Research, 21(1), 91-93. Full Article

ANTIVIRAL

Lee, J. B., Yamagishi, C., Hayashi, K., & Hayashi, T. (2011). Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum. Bioscience, Biotechnology, and Biochemistry, 75(3), 459-465. Full Article

Shukla, H. S., Dubey, P., & Chaturvedi, R. V. (1989). Antiviral properties of essential oils of Foeniculum vulgare and Pimpinella anisum L. Agronomie, 9(3), 277-279. Full Article

‍ANTI-INFLAMMATORY

 Iannarelli, R., Marinelli, O., Morelli, M. B., Santoni, G.,Amantini, C., Nabissi, M., & Maggi, F. (2018). Aniseed (Pimpinella anisum L.) essential oil reduces pro-inflammatory cytokines and stimulates mucus secretion in primary airway bronchial and tracheal epithelial cell lines. Industrial Crops and Products, 114,81-86. Full Article

HEPATOPROTECTIVE

Cengiz, N., Ozbek, H., & Him, A. (2008). Hepatoprotective effects of Pimpinella anisum seed extract in rats. Pharmacologyonline, 3, 870-874. Full Article

RELAXANT

Tirapelli, C. R., de Andrade, C. R., Cassano, A. O., De Souza, F. A., Ambrosio, S. R., da Costa, F. B., & de Oliveira, A. M. (2007). Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. Journal of Ethnopharmacology, 110(1), 23-29. Full Article

Boskabady, M. H., & Ramazani-Assari, M. (2001). Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism (s). Journal of Ethnopharmacology, 74(1), 83-88. Full Article

VARIOUS PROPERTIES

Shojaii, A., & Abdollahi Fard, M. (2012). Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharmaceutics, 2012. Full Article

"This is the best herb I have taken for clearing "brain fog." I could feel immediate effects as soon as I began taking it!" -K.F.

"This has worked wonders for me. I am now able to bring up words faster and it has improved my sleep." -J.M.

General Detox Aid: Take 10 drops in 4 oz. of water 1-2 times daily. 

Mild Toxicity, Brain Fog: Take 10 drops 3-4 times daily.  May be taken several times per day as needed.  

Moderate to Severe Toxicity, Herxheimer Reaction (healing crisis): take 10 drops every 10-15 minutes in 2 oz. of water until symptoms are resolved.  Can also put 2 droppers full (approximately 60 drops) in at least 16 oz. of water and sip over a 2-hour period, repeating until symptoms are resolved.  

Note: This product should be used with 10 drops of Burbur or Parsley for more complete elimination of toxins (in the same water).

An acute Oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Pinella did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.  Full Article

Pinella – Brain & Nerve Cleanse is an herbal extract made from Pimpinella anisum. It has been used by indigenous groups for hundreds of years. Pinella is an integral component of a Lyme disease protocol developed by William Lee Cowden, MD.  Dr. Cowden and other health care professionals report that it is very effective in eliminating both man-made toxins and biotoxins from the brain, the spinal cord and peripheral nerves. Both patients and health care professionals also report that many times there is a significant reduction in brain fog, even after only one dose.

ANALGESIC

ANODYNE

ANTI-BACTERIAL

ANTI-CONVULSANT

ANTI-FUNGAL

ANTI-MICROBIAL

ANTIOXIDANT

ANTIVIRAL

APHRODISIAC

AROMATIC

CARMINATIVE

DIAPHORIC

DISINFECTANT

DIURETIC

DYSMENORRHEA

GALACTAGOGUE

HYPOGLYCEMIC

HYPOLIPIDEMIC

MENOPAUSAL HOT FLASHES

MUSCLE RELAXANT

NERVINE

STIMULANT

SUDORIFIC

FATTY LIVER DISEASE

Asadollahpoor, A., Abdollahi, M., & Rahimi, R. (2017). Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 22. Article

CANCER

AlSalhi, M. S., Devanesan, S., Alfuraydi, A. A., Vishnubalaji, R., Munusamy, M. A., Murugan, K., ... & Benelli, G. (2016). Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells. International Journal of Nanomedicine, 11, 4439. Full Article

Fitsiou, E., Mitropoulou, G., Spyridopoulou, K., Tiptiri-Kourpeti, A., Vamvakias, M., Bardouki, H., ... & Pappa, A. (2016). Phytochemical Profile and evaluation of the biological activities of essential oils derived from the Greek aromatic plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita. Molecules, 21(8), 1069. Full Article

Kadan, S., Rayan, M., & Rayan, A. (2013). Anticancer activity of anise (Pimpinella anisum L.) seed extract. The Open Nutraceuticals Journal, 6(1). Full Article

DEPRESSION

Shahamat, Z., Abbasi-Maleki, S., & Motamed, S. M. (2016). Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice. Avicenna journal of phytomedicine, 6(3), 322. Full Article

DIABETES

Shobha, R. I., Rajeshwari, C. U., & Andallu, B. (2013). Anti-peroxidative and anti-diabetic activities of aniseeds (Pimpinella anisum L.) and identification of bioactive compounds. American Journal of Phytomedicine and Clinical Therapeutics, 1(5), 516-527. Full Article

ANTIBACTERIAL

Foroughi, A., Pournaghi, P., Tahvilian, R., Zangeneh, M. M., Zangeneh, A., & Moradi, R. (2016). Assessment of chemical composition and antibacterial effects of Anethole-rich hydroalcoholic extract of Pimpinella anisum. International Journal of Pharmaceutical and Clinical Research, 8(11), 1459-1463. Full Article

Al Maofari, A., El Hajjaji, S., Debbab, A., Zaydoun, S., Ouaki, B., Charof, R., ... & Mosaddak, M. (2013). Chemical composition and antibacterial properties of essential oils of Pimpinella Anisum L. growing in Morocco and Yemen. Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry, 14(1), 11. Full Article

Al-Bayati, F. A. (2008). Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts. Journal of Ethnopharmacology, 116(3), 403-406. Full Article

Akhtar, A., Deshmukh, A. A., Bhonsle, A. V., Kshirsagar, P. M., & Kolekar, M. A. (2008). In vitro antibacterial activity of Pimpinella anisum fruit extracts against some pathogenic bacteria. Veterinary World, 1(9), 272-274. Full Article

ANTIOXIDANT

Rebey, I. B., Wannes, W. A., Kaab, S. B., Bourgou, S., Tounsi, M. S., Ksouri, R., & Fauconnier, M. L. (2019). Bioactive compounds and antioxidant activity of Pimpinella anisum L. accessions at different ripening stages. Scientia Horticulturae, 246, 453-461. Full Article

Tavallali, V., Rahmati, S., & Bahmanzadegan, A. (2017). Antioxidant activity, polyphenolic contents and essential oil composition of Pimpinella anisum L. as affected by zinc fertilizer. Journal of the Science of Food and Agriculture, 97(14), 4883-4889. Full Article

Jamshidzadeh, A., Heidari, R., Razmjou, M., Karimi, F., Moein, M. R., Farshad, O., ... & Shayesteh, M. R. H. (2015). An in vivo and in vitro investigation on hepatoprotective effects of Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity. Iranian Journal of Basic Medical Sciences, 18(2), 205. Full Article

Singh, G., Kapoor, I. P. S., Singh, P., de Heluani, C. S., & Catalan, C. A. N. (2008). Chemical composition and antioxidant potential of essential oil and oleoresins from anise seeds (Pimpinella anisum L.). International Journal of Essential Oil Therapeutics, 2(3), 122-130. Full Article

Gülçın, İ., Oktay, M., Kıreçcı, E., & Küfrevıoǧlu, Ö. İ. (2003). Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chemistry, 83(3), 371-382. Full Article

ANTICONVULSANT

Karimzadeh, F., Hosseini, M., Mangeng, D., Alavi, H., Hassanzadeh, G. R., Bayat, M., ... & Gorji, A. (2012). Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. BMC Complementary and Alternative Medicine, 12(1), 76. Full Article

Pourgholami, M. H., Majzoob, S., Javadi, M., Kamalinejad, M., Fanaee, G. H. R., & Sayyah, M. (1999). The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. Journal of Ethnopharmacology, 66(2), 211-215. Full Article

‍ANTIFUNGAL

El-Said, A. H. M., & Goder, E. (2014). Antifungal activities of Cuminum cyminum and Pimpinella anisum essential oils. Int. J. Curr. Microbiol. App. Sci, 3(3), 937-944. Full Article

Yazdani, D., Rezazadeh, S. H., Amin, G. H., Abidin, Z., Shahnazi, S., & Jamalifar, H. (2009). Antifungal activity of dried extracts of anise (Pimpinella anisum L.) and star anise (Illicium verum Hook. f.) against dermatophyte and saprophyte fungi. Journal of Medicinal Plants, 1(29), 24-29. Full Article

Sharifi, R., Kiani, H., Farzaneh, M., & Ahmadzadeh, M. (2008). Chemical composition of essential oils of Iranian Pimpinella anisum L. and Foeniculum vulgare miller and their antifungal activity against post harvest pathogens. Journal of Essential Oil Bearing Plants, 11(5), 514-522. Full Article

Kosalec, I., Pepeljnjak, S., & Kuštrak, D. (2005). Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharmaceutica, 55(4), 377-385. Full Article

Shukla, H. S., & Tripathi, S. G. (1987). Antifungal substance in the essential oil of anise (Pimpinella anisum L.). Agricultural and Biological Chemistry, 51(7), 1991-1993. Full Article

Alrasheid, A. A., Abdallah, B. S., & Ali, A. O. (2018). In Vitro Antimicrobial Activity and GC-MS Analysis of Seed Extracts from Pimpinella anisum L. Journal of Drug Design and Medicinal Chemistry, 4(2), 16-21. Full Article

ANTIMICROBIAL

Mohamed, H. S. A. A., Abdelgadir, W. S., & Almagboul, A. Z. (2015). In vitro antimicrobial activity of Anise seed (Pimpinella anisum L.). International Journal of Advanced Research, 3(1), 359-367. Full Article

Mohammed, M. J. (2009). Isolation and identification of Anethole from Pimpinella anisum L. fruit oil. Anantimicrobial study. J Pharma Res 2009; 915, 919. Full Article

Gende, L. B., Maggi, M. D., Fritz, R., Eguaras, M. J., Bailac, P. N., & Ponzi, M. I. (2009). Antimicrobial activity of Pimpinella anisum and Foeniculum vulgare essential oils against Paenibacillus larvae. Journal of Essential Oil Research, 21(1), 91-93. Full Article

ANTIVIRAL

Lee, J. B., Yamagishi, C., Hayashi, K., & Hayashi, T. (2011). Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum. Bioscience, Biotechnology, and Biochemistry, 75(3), 459-465. Full Article

Shukla, H. S., Dubey, P., & Chaturvedi, R. V. (1989). Antiviral properties of essential oils of Foeniculum vulgare and Pimpinella anisum L. Agronomie, 9(3), 277-279. Full Article

‍ANTI-INFLAMMATORY

 Iannarelli, R., Marinelli, O., Morelli, M. B., Santoni, G.,Amantini, C., Nabissi, M., & Maggi, F. (2018). Aniseed (Pimpinella anisum L.) essential oil reduces pro-inflammatory cytokines and stimulates mucus secretion in primary airway bronchial and tracheal epithelial cell lines. Industrial Crops and Products, 114,81-86. Full Article

HEPATOPROTECTIVE

Cengiz, N., Ozbek, H., & Him, A. (2008). Hepatoprotective effects of Pimpinella anisum seed extract in rats. Pharmacologyonline, 3, 870-874. Full Article

RELAXANT

Tirapelli, C. R., de Andrade, C. R., Cassano, A. O., De Souza, F. A., Ambrosio, S. R., da Costa, F. B., & de Oliveira, A. M. (2007). Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. Journal of Ethnopharmacology, 110(1), 23-29. Full Article

Boskabady, M. H., & Ramazani-Assari, M. (2001). Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism (s). Journal of Ethnopharmacology, 74(1), 83-88. Full Article

VARIOUS PROPERTIES

Shojaii, A., & Abdollahi Fard, M. (2012). Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharmaceutics, 2012. Full Article

"This is the best herb I have taken for clearing "brain fog." I could feel immediate effects as soon as I began taking it!" -K.F.

"This has worked wonders for me. I am now able to bring up words faster and it has improved my sleep." -J.M.

General Detox Aid: Take 10 drops in 4 oz. of water 1-2 times daily. 

Mild Toxicity, Brain Fog: Take 10 drops 3-4 times daily.  May be taken several times per day as needed.  

Moderate to Severe Toxicity, Herxheimer Reaction (healing crisis): take 10 drops every 10-15 minutes in 2 oz. of water until symptoms are resolved.  Can also put 2 droppers full (approximately 60 drops) in at least 16 oz. of water and sip over a 2-hour period, repeating until symptoms are resolved.  

Note: This product should be used with 10 drops of Burbur or Parsley for more complete elimination of toxins (in the same water).

An acute Oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Pinella did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.  Full Article